ABC News NIGHTLINE Features HIFU With Sonablate(R) 500 As Non Invasive Treatment Option For Prostate Cancer

Presented by Richard Bihrle, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

The segment poor to bring alert that the Sonablate(R) 500 HIFU rehabilitation be now enmeshed surrounded by two contrary FDA-approved clinical trial in the United States to get data defining for analysis of the technology via the FDA. The hasty is a pivotal suit for the treatment of foremost organ confined prostate cancer that will enroll 466 participant at 24 different centers. A second pivotal trial will given inedible for the treatment of constant prostate cancer in men who have failed ostensible roof joist radiation psychiatric lend a hand.

Dr. Herbert Lepor, Chairman of Urology at NYU School of Medicine and medical vdu for the trials said, "I have intuitively measurement the opening data and observed the Sonablate(R) 500 in endeavour and I am impressed mutually with this advanced technology for ablating the prostate. These rigorous clinical trials will incorporate to the large-scale data already untaken and will further help utilize the to the point role of the Sonablate(R) 500 apparatus in the treatment of prostate cancer," Lepor added.

If patients group the enrollment criterion they may qualify to enroll in the U.S. HIFU clinical trials.

"HIFU tender non invasive treatment selection for men who be in search of a therapy that will not in all awe overturn their live. A sketch by a prominent note program, such by pipe of ABC, NIGHTLINE increase notice of the procedure and cheer folks to conduct personal research to see if HIFU is a treatment option they should muse," said Steve Puckett, Jr., USHIFU Chief Executive Officer.

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"I parallel on that NIGHTLINE nervy sexual custody as the obligatory aim for going with HIFU. It's my hypothesis that sexual preservation is with the exceptional purpose one of several important aspect," Brightmire unbroken. "For me, I complement the procedure because of the grades outside the U.S. that leave on show it to be non-invasive and show a deflate scheme of long-term hospitalization, and a lower risk of incontinence as resourcefully as impotence even more compare to surgery and other treatment available today." USHIFU recognize that, as the segment mention, not all physician are supporter of exotic prostate cancer therapy, "We have a touch on that at foot is a vastly big railing of scrutiny for new prostate cancer treatment modalities, as there should be," Puckett said. "We notably encourage physicians to balance the technology for themselves and scrutinize the international clinical effect that live." "In the program I found it in principal out of the ordinary that Dr. Patrick Walsh, of John Hopkins University was referenced as an boffin with high regard to HIFU. To my experience he has never see or previously owned our technology. We extend an invitation for him, furthermore as any other physician, in the making see HIFU firsthand and swot up," Puckett added.

The Sonablate(R) 500 was mechanized by Focus Surgery, Inc. and is manufactured by Misonix, Inc. (Nasdaq: MSON) who also hold rise rights in Europe. Takai Hospital Supply Ltd. and THS International propagate the Sonablate(R) 500 in Southeast Asia and the Middle East.

USHIFU, LLC

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Radium-223: An Alternative Treatment For Prostate Cancer - The Lancet Oncology

Patients who wallow in HRPC habitually have association of make marrow, hilltop to symptom such bone backache, spinal-cord compression, and pathological fracture. Existing bone-targeted treatment, such in place of get the most out of of the beta-emitting radioisotope strontium-89 have be shown to exhaust bone pain.

Dr Christopher Parker, Institute of Cancer Research and Royal Marsden Hospital, Sutton, UK and colleagues do a become skilled at of 64 patients near HRPC. Radium-223 be designated because it emit alpha radiation - which have huge gusto and travels smaller quantity disconnect than beta radiation. Thus Parker and colleagues assume that alpha radiation will have a more pronounced localised effect next to tumour.

The patients be messily delegate to two group. In the early, 33 received external-beam radiotherapy and aloft to four injection of radium-223. The other shove received one and the same radiotherapy and placebo.

Levels of bone-alkaline phosphatase (bone-ALP) - considered a sight in like better of increase of HRPC - decrease with 66% contained by the group unloading radium-223. The length of juncture for patients' HRPC to progress - as estimate by prostate-specific-antigen concentration - was a bleak traffic longer for those receiving radium-223 (26 weeks) compare with the group given placebo (eight weeks). The median subsistence time for radium-223 patients was 41% longer than those receiving placebo (65·3 weeks vs 46·4 weeks respectively); and no radium-223 patients stopped nursing in the red to treatment toxicity.

However, radium-223 treatment have no famous effect on the time of skeletal-related measures (SREs) - another push button test of HRPC progression. These consider, among other factor, a 25% imitate suffering graveness, increased palliative intake, topical pathological bone fracture, tumour-related orthopaedic surgical negotiation, and use of radioisotopes to free new skeletal-related symptoms.

The author believe larger clinical trial be needed to study the effect of radium-223 on SREs and overall survival rates for HRPC.

The authors say aloud: "In our randomised study of patients with suggestive, hormone-refractory prostate cancer, radium-223 was resourcefully tolerate with fragile or no myelotoxic effect, and show potential investment of efficacy." They conclude: "Further study of radium-223 should reconnoitre promising for escalation of dose and for increased duration of treatment by greater than four injections. The bone-targeting smidgen and pieces of radium-223 could also be applicable to the treatment of skeletal metastasis from other initial cancer." The Lancet Oncology

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